All of Us (AoU) Research Program - NIH

The All of Us Research Program, led by the National Institutes of Health, is building one of the largest biomedical data resources of its kind with health data from a diverse group of participants across the United States, with an emphasis on reaching historically underrepresented populations in biomedical research. This longitudinal cohort study seeks to advance precision medicine and improve human health through partnering with one million diverse individuals nationwide. The All of Us datasets include:

• Electronic Health Records (EHRs): Participants have the option to share EHR data, which is standardized using the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM).
• Biosamples and Bioassays: DNA is extracted via blood, urine, or saliva for subsequent genomic analysis.
• Mobile Health Data: Biometric data like heart rate and blood pressure are tracked using wearable devices.
• Physical Measurements: At the participant's first appointment, trained All of Us staff members measure and record information such as height, weight, BMI, waist and hip circumferences, blood pressure, heart rate, pregnancy status, and wheelchair use.
• Surveys: The database features a total of eight surveys, with The Basics, Lifestyle, and Overall Health being the three primary ones. For more information about the additional surveys and to explore their content, please visit the Survey Explorer.

The All of Us Research Hub stores health data from the All of Us Research Program. The Research Hub houses one of the largest, most diverse, and most broadly accessible datasets ever assembled. There are three tiers of data access:

• Public Tier: The dataset contains only aggregate data with identifiers removed. These data are available to everyone through Data Snapshots and the Data Browser. Anyone can explore aggregate data including genomic variants, survey responses, physical measurements, electronic health record information, and wearables data.
• Registered Tier: The curated dataset contains deidentified individual-level data, available only to registered researchers on the Researcher Workbench. The Registered Tier currently includes data from electronic health records (EHRs), wearables, and surveys, as well as physical measurements taken during participant enrollment.
• Controlled Tier: The dataset contains genomic data in the form of whole genome sequencing (WGS) and genotyping arrays, previously suppressed demographic data fields from EHRs and surveys, and unshifted dates of events, available only to registered researchers. 

Your access to these tiers depends on the Data Use Registration Agreement (DURA) your institution has with the All of Us Research Program. SJSU has Registered and Controlled Tier access.